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3-triazole linkages without a copper catalyst
and antibody research
Hemoglobin Subunit Beta (2-7)-Fru(2)
glycomimetic research
36 / A β-D-galactose ligand equipped with a terminal alkyne through a hydrophilic PEG3 spacer
PE034000: α-NeuAc-PEG3-Azide Pack Size:25 mg 3-triazole linkages without a copperC17H30N4O11 466. 44 An N acetylneuraminic acid (Neu5Ac) ligand equipped with an azide handle through a hydrophilic PEG3 spacer. The terminal azide couples to alkynes via copper catalyzed azide alkyne cycloaddition (CuAAC) or to DBCO and related strained alkynes via copper free click chemistry, forming stable 1,2,3 triazole linkages. This terminal sialic acid (Neu5Ac) residue is a recognition element for Siglecs and sialic acid binding proteins, and
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