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27 / An α-mannose-6-phosphate (Man6P) ligand
Triantennary β-D-GalNAc tetraethyleneglycol Dibenzocyclooctyne
Thr131 and Thr144
N-α-Fmoc-O-β-(2-acetamido-2-deoxy-3
cleaving the β-glycosidic bond to release free GlcNAc and 4-nitrophenol
PE135010: β-GalNAc-PEG3-Thiol Pack Size:10 mg 27 / An α-mannose-6-phosphate (Man6P)C14H27NO8S 369. 43 A D N acetylgalactosamine (GalNAc) ligand equipped with a free thiol through a hydrophilic PEG3 spacer. The thiol reacts with maleimides to form stable thioether conjugates or with other thiols to form disulfide bonds; it is also compatible with thiol gold chemistry for surface immobilization. This compound enables the construction of hepatocyte targeted therapeutics and research tools that exploit the asialoglycoprotein receptor
