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While other cards that discard your cards give you some immediate benefit on its own like summoning creatures, drawing cards, or also force your opponent to discard cards as well, One With Nothing has no direct benefit by itself and you need other cards to make use of it

Source: Wizards of the Coast Magic: The Gathering Video Game(s) Magic: The Gathering, Magic: The Gathering Arena

Get ready for enters-the-battlefield overload

I have excluded all Enchanteds from this list

1-mana counterspells often get people excited though, and this blue instant could bump up a number of decks in Constructed formats as well as see cEDH play, #34